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Accession Type:
Network
AMPAR_traff_
model1
Shared_Object_
AMPAR_traff_
model1
CaMKII
CaM
 Molecule
 Reaction
PP1
PP2B
PP1_PSD
PKA
AC
AMPAR
AMPAR_memb

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Molecule List for pathway CaM (Pathway Number 246)

 Name Initial Conc. (uM) Volume (fL) Buffered
1CaM26.33330.09No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
2CaM-Ca300.09No
   
3CaM-Ca3-PSD00.01No
   
4CaM-Ca400.09No
   
5CaM-Ca4-PSD00.01No
   
6CaM-PSD26.33330.01No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
7CaM-TR2-Ca200.09No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
8CaM-TR2-Ca2-PSD00.01No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
9neurogranin100.09No
    Also known as RC3 and p17 and BICKS. Conc in brain >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995 but others say less without any #s. Conc in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding ....
10neurogranin*00.09No
    The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)
11neurogranin*_PSD00.01No
    The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)
12neurogranin-CaM00.09No
   
13neurogranin-CaM_PSD00.01No
   
14neurogranin_PSD100.01No
    Also known as RC3 and p17 and BICKS. Conc in brain >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995 but others say less without any #s. Conc in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding ....


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