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Accession Type:
Network
AMPAR_traff_
model1
Shared_Object_
AMPAR_traff_
model1
CaMKII
CaM
PP1
PP2B
PP1_PSD
PKA
AC
 Molecule
 Enzyme
 Reaction
AMPAR
AMPAR_memb

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Molecule List for pathway AC (Pathway Number 251)

 Name Initial Conc. (uM) Volume (fL) Buffered
1AC10.07410.09No
    Starting conc at 20 nM. Reduced conc to 10 nM, 14.8. Arnold 17 Feb 2005. Raised conc back to about 18 nM, for an nInit of precisely 1. 18 Feb. Doubled conc, to compensate for reduced ATP. 18 Feb. Doublec conc again, halved Vmax.
2AC1-CaM00.09No
    This version of cyclase is Calmodulin activated. Gs stims it but betagamma inhibits.
3AC20.07410.09No
    Starting at 0.015 uM. 17 Feb 2005: Raised slightly so as to have integer number of molecules. 18 Feb 2005: Doubled, to compensate for reduced ATP.
4AC2*00.09No
    This version is activated by Gs and by a betagamma and phosphorylation.
5AMP00.09No
   
6ATP20000.09Yes
    ATP is present in all cells between 2 and 10 mM. See Lehninger
7CaM.PDE100.09No
    Activity up 6x following Ca-CaM binding.
8cAMP00.09No
    The conc of this has been a problem. Schaecter and Benowitz use 50 uM, but Shinomura et al have < 5. So I have altered the cAMP-dependent rates in the PKA model to reflect this.
9cAMP-PDE0.55560.09No
    The levels of the PDE are not known at this time. However, enough kinetic info and info about steady-state levels of cAMP etc are around to make it possible to estimate this. 18 Feb 2005: After some playing with initial conc, it is now back at 0.5 uM.
10cAMP-PDE*00.09No
    This form has about 2X activity as plain PDE. See Sette et al JBC 269:28 18271-18274 1994.
11cAMP_in_dend05No
    Assume a 5 uM long segment of 1 uM^2 Xsection dendrite.
12PDE12.59260.09No
    CaM-Dependent PDE. Amount calculated from total rate in brain vs. specific rate.


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