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Accession Type:
Network
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Shared_Object_
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PKC
PLA2
PLCbeta
Gq
MAPK
Ras
CaMKII
CaM
PP1
PP2B
PKA
 Molecule
 Reaction
AC

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Molecule List for pathway PKA (Pathway Number 30)

 Name Initial Conc. (uM) Volume (fL) Buffered
1inhibited-PKA01000No
   
2PKA-inhibitor0.251000No
   
3R2-cAMP401000No
   
4R2C-cAMP401000No
    R-dimer bound to 4 cAMP molecules.
5R2C20.51000No
    PKA: Protein kinase activated by cAMP.
R2C2 complex consists of 2 catalytic (C) subunits, and the R-dimer. There are two types of cAMP binding sites termed A and B according to the rate with which they exchange bound labelled nucleotide.
Dagfinn Ogreid and Stein Ove Doskeland (1981) Int.J.Biochem. 13(1):1-19
Physiological concentration of PKA = 0.59 uM (cardiac myocyte)
Jeffrey J. Saucerman et al (2003) J.Biol.Chem. 278(48):47997-48003
6R2C2-cAMP01000No
    R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to site B1 on the regulatory subunit.
7R2C2-cAMP201000No
    R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to each of the B sites on the regulatory subunit.
8R2C2-cAMP301000No
    R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 3 cAMP molecules bound to it.
9R2C2-cAMP401000No
    R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 4 cAMP molecules bound to it. All the regulatory subunits now have cAMP bound. This state is ready to dissociate and to release the catalytic subunit.


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