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Accession Type:
Network
Ajay_Bhalla_
2004_PKM_Tuning
PKC
Shared_Object_
Ajay_Bhalla_
2004_PKM_tuning
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
 Molecule
 Reaction
AC
PKM

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Molecule List for pathway PKA (Pathway Number 326)

 Name Initial Conc. (uM) Volume (fL) Buffered
1inhibited-PKA01.5No
2PKA-inhibitor0.251.5No
    About 25% of PKA C subunit is dissociated in resting cells without having any noticable activity. Doskeland and Ogreid Int J biochem 13 pp1-19 suggest that this is because there is a corresponding amount of inhibitor protein.
3R2-cAMP401.5No
    Starts at 0.15 for the test of fig 6 in Smith et al, but we aren't using that paper any more.
4R2C-cAMP401.5No
5R2C20.51.5No
    This is the R2C2 complex, consisting of 2 catalytic (C) subunits, and the R-dimer. See Taylor et al Ann Rev Biochem 1990 59:971-1005 for a review. The Doskeland and Ogreid review is better for numbers. Amount of PKA is about .5 uM.
6R2C2-cAMP01.5No
    CoInit was .0624
7R2C2-cAMP201.5No
8R2C2-cAMP301.5No
9R2C2-cAMP401.5No


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