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Accession Type:
Network
mkp1_feedback_
effects
Shared_Object_
mkp1_feedback_
effects
Sos
PKC
 Molecule
 Reaction
MAPK
PLA2
Ras
PDGFR

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Molecule List for pathway PKC (Pathway Number 34)

 Name Initial Conc. (uM) Volume (fL) Buffered
1PKC-AA*01000No
    This is the membrane-bound and active form of the PKC-AA complex.
2PKC-basal*0.021000No
    This is the basal PKC activity which contributes about 2% to the maximum.
3PKC-Ca01000No
    This intermediate is strongly indicated by the synergistic activation of PKC by combinations of DAG and Ca, as well as AA and Ca. PKC by definition also has a direct Ca-activation, to which this also contributes.
4PKC-Ca-AA*01000No
    Membrane bound and active complex of PKC, Ca and AA.
5PKC-Ca-DAG01000No
    This is the active PKC form involving Ca and DAG. It has to translocate to the membrane.
6PKC-Ca-memb*01000No
    This is the direct Ca-stimulated activity of PKC.
7PKC-cytosolic11000No
    Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells Kikkawa et al 1982 JBC 257(22):13341 have PKC levels in brain at about 1 uM. The cytosolic form is the inactive PKC. This is really a composite of three isoforms: alpha, beta and gamma which have slightly different properties and respond to different combinations of Ca, AA and DAG.
8PKC-DAG01000No
    This is a DAG-bound intermediate used in synergistic activation of PKC by DAG and AA.
9PKC-DAG-AA01000No
    Complex of PKC, DAG and AA giving rise to synergistic activation of PKC by DAG and AA at resting Ca.
10PKC-DAG-AA*01000No
    Membrane translocated form of PKC-DAG-AA complex.
11PKC-DAG-memb*01000No
    Active, membrane attached form of Ca.DAG.PKC complex.


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