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Accession Type:
Network
Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Shared_Object_
Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
PKC
PLA2
PLCbeta
Ras
Gq
MAPK
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
 Molecule
 Reaction
PP2B
PKA
AC
MKP3
PKM

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Molecule List for pathway PP1 (Pathway Number 341)

 Name Initial Conc. (uM) Volume (fL) Buffered
1I11.81.5No
    I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183). We treat it as non-compet, so it just turns the enz off without interacting with the binding site. Cohen et al ann rev bioch refer to results where conc is 1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM, we need >= 1.8 uM.
2I1*0.0011.5No
    Dephosph is mainly by PP2B
3PP1-I101.5No
4PP1-I1*01.5No


Pathway Details  Molecule List  Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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