 |  |  CaMKII |
|  |  Molecule |
| | Enzyme |
| | Reaction |
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Reaction List for pathway CaMKII (Pathway Number 174) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
Autonomous-bind-
CaMCa4 | kf
(uM^-1 s^-1) | 0
(s^-1) | - | - | CaMCa4
Autonomous
| Trapped-T286
| | 2 |
Autonomous_
lose_CaMCa4 | kf
(s^-1) | 0
(uM^-1 s^-1) | - | - | Trapped-T286
| Autonomous
CaMCa4
| | | Holmes says that this rate is variable, and depends on Ca conc. It is 0.1 when [Ca] = 10 nM, and 0.00355/sec when [Ca] is 1.0 For our purposes, we assume a good steady approx to this rate is 0.02. | | 3 |
CaMKII-bind-CaM | kf
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 13500(uM) | - | CaM
CaMKII
| CaMKII-CaM
| | 4 |
CaMKII-bind-CaMC
a | kf
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 3375.0084(uM) | - | CaMCa
CaMKII
| CAMKII-CaMCa
| | 5 |
CaMKII-bind-CaMC
a2 | kf
(uM^-1 s^-1) | 2250
(s^-1) | Kd(bf) = 1125(uM) | - | CaMCa2
CaMKII
| CaMKII-CaMCa2
| | 6 |
CaMKII-bind-CaMC
a3 | kf
(uM^-1 s^-1) | 22.5
(s^-1) | Kd(bf) = 0.225(uM) | - | CaMCa3
CaMKII
| CaMKII-CaMCa3
| | 7 |
CaMKII-bind-CaMC
a4 | kf
(uM^-1 s^-1) | 4.5
(s^-1) | Kd(bf) = 0.045(uM) | - | CaMCa4
CaMKII
| CaMKII-CaMCa4
| | 8 |
CaMKII-CaM-bind-
Ca | kf
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 5(uM) | - | CaMKII-CaM
Ca
| CAMKII-CaMCa
| | 9 |
CaMKII-CaMCa-bin
d-Ca | kf
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 0.2(uM) | - | CAMKII-CaMCa
Ca
| CaMKII-CaMCa2
| | 10 |
CaMKII-CaMCa2-bi
nd-Ca | kf
(uM^-1 s^-1) | 2
(s^-1) | Kd(bf) = 0.02(uM) | - | CaMKII-CaMCa2
Ca
| CaMKII-CaMCa3
| | 11 |
CaMKII-CaMCa3-bi
nd-Ca | kf
(uM^-1 s^-1) | 100
(s^-1) | Kd(bf) = 1(uM) | - | CaMKII-CaMCa3
Ca
| CaMKII-CaMCa4
| | 12 |
dephosph_T286 | kf
(s^-1) | 0
(s^-1) | - | - | Autonomous
| CaMKII
| | 13 |
dephosph_T305 | kf
(s^-1) | 0
(s^-1) | - | - | Capped
| Autonomous
| | | This is treated as a separate reaction because it is independent of the CaMKII concentration or activation state, unlike the forward reaction in the Holmes paper. Holmes tries a range of rates for this step, and says it doesn't matter much. | | 14 |
Dephosph_
trapped_T286 | kf
(s^-1) | 0
(s^-1) | - | - | Trapped-T286
| CaMKII-CaMCa4
| | | This rate is for the back reaction for the step represented here as a separate enzyme, but by Holmes as a single reversible reaction. Here it is treated as separate because the forward reaction is dependent on activity levels of the CaMKII, whereas the back reaction is not. Holmes tries a range of values for this back-reaction and says that it doesn't matter much. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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