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Accession Type:
Network
Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Shared_Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13
PKC
MAPK
Ras
CaM
PKM
chain
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[1]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[2]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[3]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[4]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[5]
PKC
MAPK
Ras
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[6]
CaM
PKM
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[7]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[8]
PKC
MAPK
Ras
 Molecule
 Enzyme
 Reaction
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[9]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[10]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[11]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[12]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[13]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[14]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[15]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[16]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[17]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[18]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[19]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[20]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[21]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[22]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13_[23]
PKC
MAPK
Ras
CaM
PKM

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Reaction List for pathway Ras (Pathway Number 584)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 CaM-bind-GEFkf
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.005(uM)-inact-GEF
CaM-Ca4
CaM-GEF
  We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995
2 dephosph-GAPkf
(s^-1)
0
(s^-1)
--GAP*
GAP
  Assume a reasonably good rate for dephosphorylating it, 1/sec
3 dephosph-GEFkf
(s^-1)
0
(s^-1)
--GEF*
inact-GEF
4 Ras-intrinsic-GT
Pase
kf
(s^-1)
0
(s^-1)
--GTP-Ras
GDP-Ras
  This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4


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