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Reaction List for pathway MAPK (Pathway Number 61) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
MKP-1**dephosph | kf
(s^-1) | 0
(s^-1) | - | - | MKP-1**
| MKP-1-ser359*
| | | 24 Apr 2K, based on 12 Feb 2K: Scaled up 10x to kf=0.01, kb=0 | | 2 |
MKP-1*dephosph | kf
(s^-1) | 0
(s^-1) | - | - | MKP-1-ser359*
| MKP-1
| | | 24 Apr 2K: Based on 12 Feb 2K: Scaled up 10x so kf=0.01, kb=0 | | 3 |
MKP-1-basal-synt
h | kf
(s^-1) | 0
(s^-1) | - | - | MKP-1-gene
| MKP-1
| | | 3 Feb 2000. The levels of basal MAPK are so low that we need to have a basal mechanism for making MKP-1. This is easy, as the degradation tau is 45 min and basal MKP-1 levels are 2.4 nM in our model. x * 1 uM = 2.4e-3 * 0.37e-3 = 8.9e-7 May 30 2k. Basal levels shifted up a bit. kf now 1.0e-6 Jun 3 2k: kf now 8e-7 Jun 4 2k: kf = 7e-7 | | 4 |
translocation | kf
(s^-1) | 0.0001
(s^-1) | Keq = 5(uM) | - | MAPK*
| nuc_MAPK*
| | | 5 Feb 2000. A nuclear translocation step. The rates are set up so that not too much MAPK gets siphoned off. 24 Apr 2000. Based on 12 Feb model. Rates slowed down x 0.02 to kf=2e-5 kb=1e-4 | | 5 |
turnover_MKP1 | kf
(s^-1) | 0
(s^-1) | - | - | MKP-1
| Ubiquitination
| | | 3 Feb 2000. Rate of turnover of non-phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 45 min. | | 6 |
turnover_MKP1* | kf
(s^-1) | 0
(s^-1) | - | - | MKP-1-ser359*
| Ubiquitination
| | | 3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff. | | 7 |
turnover_MKP1** | kf
(s^-1) | 0
(s^-1) | - | - | MKP-1**
| Ubiquitination
| | | 3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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