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Accession Type:
Pathway
PLCbeta1
PLCbeta
 Molecule
 Enzyme
 Reaction

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Reaction List for pathway PLCbeta (Pathway Number 67)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Basalkf
(s^-1)
0
(uM^-1 s^-1)
--PIP2
DAG
IP3
  6 Nov 2001 The basal reaction rates are fixed according to the respomse curves obtained from I. Litosch, Biochem.,2000, 39, 7736-7743.
2 Ca_bind_PLCbetakf
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 1(uM)-Ca
PLCbeta
Ca.PLCbeta
  6 Nov 2001 The Kf and Kb values were fixed according to the dose response curves obtained from I.Litosch, Biochem., 2000, 39, 7736-7743.
3 Gq-bind-Ca.PLCbe
ta
kf
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.02(uM)-Gq
Ca.PLCbeta
Gq.Ca.PLCbeta
  6 Nov 2001 The Kf and Kb values were fixed according to the response curves obtained from I. Litosch, Biochem., 2000, 39, 7736-7743.
4 PA-bind-Ca.PLCbe
ta
kf
(uM^-1 s^-1)
8
(s^-1)
Kd(bf) = 8(uM)-PA
Ca.PLCbeta
PA.Ca.PLCbeta
  6 Nov 2001 The Kf and Kb values were fixed according to the dose response curves obtained from I. Litosch, Biochem., 2000, 39, 7736-7743.


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