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Accession Type:
Network
Ajay_Bhalla_
2007_ReacDiff3
Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
PKC
PLA2
MAPK
PLA2
Ras
CaM
chain
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3
PKC
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[1]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[2]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[3]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[4]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[5]
PKC
PLA2
MAPK
Ras
MAPK
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[6]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[7]
PKC
PLA2
MAPK
Ras
CaM
PKC
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[8]
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[9]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[10]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[11]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[12]
PKC
PLA2
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[13]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[14]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[15]
PKC
PLA2
MAPK
Ras
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[16]
CaM
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[17]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[18]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[19]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[20]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[21]
PKC
PLA2
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[22]
PKC
PLA2
 Molecule
 Enzyme
 Reaction
MAPK
Ras
CaM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff3_
[23]
PKC
PLA2
MAPK
Ras
CaM

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Molecule List for pathway PLA2 (Pathway Number 1059)

 Name Initial Conc. (uM) Volume (fL) Buffered
1APC30.0003125.7Yes
    arachodonylphosphatidylcholine is the favoured substrate from Wijkander and Sundler, JBC 202 pp 873-880, 1991. Their assay used 30 uM substrate, which is what the kinetics in this model are based on. For the later model we should locate a more realistic value for APC.
2DAG-Ca-PLA2*0125.7No
3PIP2-Ca-PLA2*0125.7No
4PIP2-PLA2*0125.7No
5PLA2*0125.7No
6PLA2*-Ca0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
7PLA2-Ca*0125.7No
8PLA2-cytosolic0.4125.7No
    Calculated cytosolic was 20 nm from Wijkander and Sundler However, Leslie and Channon use about 400 nM. Need to confirm, but this is the value I use here. Another recalc of W&S gives 1uM


Pathway Details  Molecule List   Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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