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Parameters for CaMKII (Pathway Number 106)
Pathway Basic Parameters
| Pathway Name||CaMKII|
| Pathway Entry Number || 106|
| Accession Number ||23|
| Accession Name ||NonOsc_Ca_IP3metabolism|
| Species ||Generic mammalian|
| Tissue ||Brain - Neuronal|
| Related Pathways ||13,
| Notes||Main reference here is the review by Hanson PI, Schulman H. Annu Rev Biochem. 1992;61:559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson PI, Schulman H. J Biol Chem. 1992 Aug 25;267(24):17216-24. The enzymes look a bit complicated. Actually it is just 3 reactions for different sites, by 4 states of CaMKII, defined by the phosphorylation state. This model approximates the fact that the enzyme is actually present as a decamer/dodecamer. It does so by treating the autophosphorylation reactions as being independent of the concentration of CaMKII. Also the rates for the autophosphorylation steps have been scaled to fit this approximation.
|This pathway is part of accession 23 and is completely specified in the file acc23.g.|
There is no separate files for just this pathway.
|Native Format (GENESIS format)|| acc23.g |
|GENESIS Format (Annotated version)|| Anno_acc23.g |
Pathway Detail Molecule List Enzyme List Reaction List
|Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR |
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