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Accession Type:
Network
Osc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos
CaRegulation
 Molecule
 Enzyme
 Reaction
Othmer-Tang-mode
l

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Enzyme List for pathway CaRegulation (Pathway Number 132)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
Ca-pump-out

Enzyme Molecule:
CaEPump
0.08999772004explicit E-S complexCa
Ca-ext
  Both affinity and Vmax of the Ca-pump are higher than those used in the model that generates non-oscillatory Ca dynamics. Km has been decreased from 0.2 to 0.09 uM and Vmax increased from 72 to 200. The parameters are constrained by the need to generate Ca oscillations by the Othmer-Tang model.


Pathway Details   Molecule List  Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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