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Accession Type:
Network

Osc_Ca_
IP3metabolism

		CaRegulation
		Molecule
		Enzyme
		Reaction

Othmer-Tang-mode
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Reaction List for pathway CaRegulation (Pathway Number 132)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.

	Name	Kf	Kb	Kd	tau	Substrate	Product
1	Ca10-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Ca5-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca10-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca5-Cal. Due to system limitations only four are entered.
2	Ca15-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Ca10-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca15-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca10-Cal. Due to system limitations only four are entered.
3	Ca20-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Ca15-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca20-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca15-Cal. Due to system limitations only four are entered.
4	Ca25-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca20-Cal	Ca25-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca20-Cal. Due to system limitations only four are entered.
5	Ca30-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Ca25-Cal Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca30-Calseq
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca25-Cal. Due to system limitations only four are entered.
6	Ca35-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca30-Calseq	Ca35-Calseq
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca30-Cal. Due to system limitations only four are entered.
7	Ca40-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca35-Calseq	Ca40-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca35-Cal. Due to system limitations only four are entered.
8	Ca5-bind-Cal	kf (uM^-5 s^-1)	1 (s^-1)	-	-	Calseq Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester	Ca5-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with one Calseq. Due to system limitations only four are entered.
9	inactivate_cap_ Ca	kf (#^-2 s^-1)	10 (s^-1)	Not applicable**	-	Ca-sequester Ca-sequester capacitive_Ca_ entry*	inact_cap_entry
	For non-oscillatory Ca dynamics Kd was set at 3 uM. This did not allow for Ca oscillations characteristic of the Othmer-Tang model. The rates here are constrained solely by the need to generate Othmer-Tang type Ca oscillations.

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration.

Pathway Details Molecule List Enzyme List Reaction List

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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