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Accession Type:
Network
cAMP_pathway
Shared_Object_
cAMP_pathway
PKA
AC
 Molecule
 Enzyme
 Reaction
Gs

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Molecule List for pathway AC (Pathway Number 136)

 Name Initial Conc. (uM) Volume (fL) Buffered
1AC0.0151000No
    AC is present at rather low levels. Here we use 0.015 uM which is meant to lump various isoforms. None of the isoforms nor the other specific regulators are included here. Jacobowitz, PhD thesis.
2AMP10001000Yes
    Assumed buffered to 1 mM. Value is irrelevant to simulation.
3ATP50001000Yes
    ATP is present in all cells between 2 and 10 mM. See Lehninger. It is assumed buffered since the metabolic activity will take care of its levels.
4cAMP-PDE0.51000No
    The levels of the PDE are not known at this time. However, enough kinetic info and info about steady-state levels of cAMP etc are around to make it possible to estimate this at about 0.5 uM.
5cAMP-PDE*01000No
    This form has about 2X activity as plain PDE. See Sette et al JBC 269:28 18271-18274 1994.
6Gs.AC01000No
    This is the active form of the cyclase.


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