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Accession Type:
Network
cAMP_pathway
Shared_Object_
cAMP_pathway
PKA
AC
 Molecule
 Enzyme
 Reaction
Gs

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Reaction List for pathway AC (Pathway Number 136)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 dephosph-PDEkf
(s^-1)
0
(s^-1)
--cAMP-PDE*
cAMP-PDE
  The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
2 Gs-bind-ACkf
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.002(uM)-AC
GTP.Ga
Gs.AC
  Half-max at around 3nM = kb/kf from fig 5 in Feinstein et al PNAS USA 88 10173-10177 1991 kf = kb/1800 = 5.56e-4 kb Ofer Jacobowitz thesis (Mount Sinai 1995) data indicates it is more like 2 nM.


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