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Accession Type:
Network
cAMP_pathway
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cAMP_pathway
PKA
AC
Gs
 Molecule
 Reaction

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Molecule List for pathway Gs (Pathway Number 137)

 Name Initial Conc. (uM) Volume (fL) Buffered
1Gbg01000No
    The Gbetagamma dimer.
2GDP.Ga01000No
    The inactive GDP-bound form of Gs alpha.
3GDP.Gabc11000No
    The resting state of Gs: GDP bound to trimer. From Pang and Sternweis JBC 265:30 18707-12 1990 we get conc est 1.6 uM to 0.8 uM. We'll use 1 uM.
4L01000Yes
    This ligand could be any of several which bind to the beta adrenergic receptor and other G-protein coupled receptors which activate AC. For the sake of argument, call it isoproterenol.
5L.R01000No
    Ligand.Receptor complex
6L.R.GDP.Gabc01000No
    This is the ternary complex, where all the action happens. There are actually a lot more steps here, including a final step where the GTP binds the L.R.Ga complex and causes the release of GTP.Ga from the L.R. For simplicity this is excluded.
7R0.08331000No
    A typical number of receptors per cell is about 50000.
8R.GDP.Gabc01000No
    Fraction of R.GDP.Gabc is about 50% of total R, from Fay et al. Biochemistry 30:5066-5075(1991) Since this is not the same receptor, this value is a bit uncertain.


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