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Accession Type:
Pathway
MAPK_osc
MAPK
 Molecule
 Enzyme
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Enzyme List for pathway MAPK (Pathway Number 139)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
1

Enzyme Molecule:
Ras-MKKKK
0.012.54Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MKKK
MKKK-P
  The Km is 10nM and Vmax is 2.5nM sec^-1. We assume that there is 1 nM of the Ras-MKKKK. From Kholodenko, 2000. If the enzymes are not flagged as Available, then this Km should be set to 0.1 to obtain oscillations.
2 Enzyme Activity:
10

Enzyme Molecule:
int5
0.01499970.54Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MAPK-P
MAPK
  The Km is 15nM and Vmax is 0.5nM.s-1 from Kholodenko, 2000
3 Enzyme Activity:
2

Enzyme Molecule:
int1
0.0080.254Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MKKK-P
MKKK
  Km is 8nM and Vmax is 0.25nM.s-1 from Kholodenko, 2000.
4 Enzyme Activity:
3

Enzyme Molecule:
MKKK-P
0.01500010.0254Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MKK
MKK-P
  Km is 15 nM and Vmax is 0.025s-1 from Kholodenko, 2000
5 Enzyme Activity:
4

Enzyme Molecule:
MKKK-P
0.01500010.0254Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MKK-P
MKK-PP
  Km is 15nM and Vmax is 0.025s-1 from Kholodenko, 2000.
6 Enzyme Activity:
5

Enzyme Molecule:
int2
0.0150.754Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MKK-PP
MKK-P
  The Km is 15nM and Vmax is 0.75nM.s-1 from Kholodenko, 2000
7 Enzyme Activity:
6

Enzyme Molecule:
int3
0.0150.754Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MKK-P
MKK
  The Km is 15nM and the Vmax is 0.75nM.s-1 from Kholodenko 2000.
8 Enzyme Activity:
7

Enzyme Molecule:
MKK-PP
0.01500010.0254Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MAPK
MAPK-P
  The Km is 15nM which is 0.015uM Vmax is 0.025s-1 from Kholodenko, 2000.
9 Enzyme Activity:
8

Enzyme Molecule:
MKK-PP
0.01500010.0254Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MAPK-P
MAPK-PP
  The Km is 15nM which is 0.015uM and Vmax is 0.025s-1 from Kholodenko, 2000
10 Enzyme Activity:
9

Enzyme Molecule:
int4
0.01499970.54Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
MAPK-PP
MAPK-P
  The Km is 15nM and Vmax is 0.5nM.s-1 from Kholodenko, 2000


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