 |  |  CaRegulation |
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Reaction List for pathway 134_dephos (Pathway Number 165) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
1pase-off | kf
(s^-1) | 0.0008
(uM^-1 s^-1) | Kd(cb) = 0.0001(uM) | - | ip1_1pase_cmplx
| inositol
IP1_pase
| | | Kf = Vmax for Ins(1)P1-1phosphatase: Gee et al, Biochem J 249, 1988. Kb necessary as estimated from percent inositol backflux calculations. This contributes to maintain Ins(1)P1 at 10% of its actual pool. | | 2 |
1pase-on | kf
(uM^-1 s^-1) | 45.72
(s^-1) | Kd(bf) = 128.0005(uM) | - | IP1(1)
IP1_pase
| ip1_1pase_cmplx
| | | Rates derived from Km for Ins(1)P1-1phosphatase: Gee et al, Biochem J 249; 1988. | | 3 |
IP1(3)_deg | kf
(s^-1) | 0.336
(s^-1) | Keq = 0.0096(uM) | 0.028sec | IP1(3)
| inositol
| | | Kf and Kb based on levels of Ins(3)P1. Kb necessary as energetics calculations show backflow from inositol to be significant. | | 4 |
ip1_syn | kf
(s^-1) | 0
(s^-1) | - | - | inositol
| IP1(1)
| | | This rxn. maintains levels of Ins(1)P1 at 44 uM basal. Actually, 90% of Ins(1)P1 is generated from PtdIns degradation (Ackermann et al, Biochem J 242(2), 1987: 517-24) but for simplicity we use a back rxn. from Inositol to generate this conc. | | 5 |
IP_4pase-inact | kf
(uM^-1 s^-1) | 19
(s^-1) | Kd(bf) = 19(uM) | - | IP_4pase
IP6
| IP_4pase_inact
| | | from Norris et al, JBC 269; 1994 |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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