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Accession Type:
Network
MAPK_network_
2003
Shared_Object_
MAPK_network_
2003
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
 Molecule
 Enzyme
 Reaction
CaMKII
CaM
PP1
PP2B
PKA
AC

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Enzyme List for pathway PLC_g (Pathway Number 215)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
PIP2_hydrolysis

Enzyme Molecule:
Ca.PLC_g
97.2222144Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
PIP2
DAG
IP3
  Mainly Homma et al JBC 263:14 1988 pp 6592, but these parms are the Ca-stimulated form. It is not clear whether the enzyme is activated by tyrosine phosphorylation at this point or not. Wahl et al JBC 267:15 10447-10456 1992 say that the Ca_stim and phosph form has 7X higher affinity for substrate than control. This is close to Wahl's figure 7, which I am using as reference.
2 Enzyme Activity:
PIP2_hydrolysis

Enzyme Molecule:
Ca.PLC_g*
19.7917574Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S
PIP2
DAG
IP3
  Mainly Homma et al JBC 263:14 1988 pp 6592, but these parms are the Ca-stimulated form. It is not clear whether the enzyme is activated by tyrosine phosphorylation at this point or not. Wahl et al JBC 267:15 10447-10456 1992 say that this has 7X higher affinity for substrate than control.


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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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