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Accession Type:
Network
EGFR_MAPK
Shared_Object_
EGFR_MAPK
MAPK
Ras
EGFR
 Molecule
 Enzyme
 Reaction
Sos

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Molecule List for pathway EGFR (Pathway Number 232)

 Name Initial Conc. (uM) Volume (fL) Buffered
1EGF01000Yes
   
2EGFR0.16671000No
    Berkers et al JBC 266 say 22K hi aff recs. Sherrill and Kyte Biochemistry 35 use range 4-200 nM. These match, lets use them.
3Internal_L.EGFR01000No
   
4L.EGFR01000No
    This is terribly simplified: there are many interesting intermediate stages, including dimerization and assoc with adapter molecules like Shc, that contribute to the activation of the EGFR.
5SHC0.51000No
    There are 2 isoforms: 52 KDa and 46 KDa (See Okada et al JBC 270:35 pp 20737 1995). They are acted up on by the EGFR in very similar ways, and apparently both bind Grb2 similarly, so we'll bundle them together here. Sasaoka et al JBC 269:51 pp 32621 1994 show immunoprecs where it looks like there is at least as much Shc as Grb2. So we'll tentatively say there is 1 uM of Shc.
6SHC*01000No
   


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