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Accession Type:
Network
AMPAR_traff_
model1
Shared_Object_
AMPAR_traff_
model1
CaMKII
CaM
PP1
PP2B
PP1_PSD
PKA
AC
AMPAR
 Molecule
 Reaction
AMPAR_memb

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Reaction List for pathway AMPAR (Pathway Number 252)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 degrade**kf
(s^-1)
0
(s^-1)
--
  • A835*845*_
    B835*845*

  • AMPAR_deg
    2 degrade*_kf
    (s^-1)
    0
    (s^-1)
    --A831*845*_B845*
    AMPAR_deg
    3 degrade_*kf
    (s^-1)
    0
    (s^-1)
    --A845*_B831*845*
    AMPAR_deg
    4 degrade__kf
    (s^-1)
    0
    (s^-1)
    --A845*_B845*
    AMPAR_deg
    5 endo_constkf
    (s^-1)
    0.0014
    (s^-1)
    Not applicable**-GluR23_M
    GluR23_I
    6 exo_reg**kf
    (#^-1 s^-1)
    0.008
    (s^-1)
    Not applicable**-
  • A835*845*_
    B835*845*

    Anchor
  • A835*845*_
    B835*845*

  • 7 exo_reg*_kf
    (#^-1 s^-1)
    0.008
    (s^-1)
    Not applicable**-A831*845*_B845*
    Anchor
    A831*845*_B845*
    8 exo_reg_*kf
    (#^-1 s^-1)
    0.008
    (s^-1)
    Not applicable**-A845*_B831*845*
    Anchor
    A845*_B831*845*
    9 exo_reg__kf
    (#^-1 s^-1)
    0.008
    (s^-1)
    Not applicable**-A845*_B845*
    Anchor
    A845*_B845*
      Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
    10 recycle**kf
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-A831*_B831*
    A831*_B831*
    Anchor
    11 recycle*_kf
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-A831*_B
    A831*_B
    Anchor
    12 recycle_*kf
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-A_B831*
    A_B831*
    Anchor
    13 recycle__kf
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-A_B
    A_B
    Anchor
    14 turnoverkf
    (s^-1)
    1
    (s^-1)
    Not applicable**-AMPAR_bulk
    A_B
      Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration.


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