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Accession Type:
Network
CaMKII_model3
Shared_Object_
CaMKII_model3
CaMKII
 Molecule
 Enzyme
 Reaction
CaM
PP1
PP2B
PP1_PSD
AC
PKA

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Molecule List for pathway CaMKII (Pathway Number 264)

 Name Initial Conc. (uM) Volume (fL) Buffered
1CaMK-thr30500.09No
    This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
2CaMKII200.09No
    Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit.
3CaMKII***00.09No
    From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
4CaMKII-CaM00.09No
   
5CaMKII-thr28600.09No
    I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
6CaMKII-thr286*-CaM00.09No
    From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
7tot_autonomous_CaMKII20.09No
   
8tot_CaM_CaMKII00.09No
   

Summed Molecule List

  Target Inputs
1 tot_autonomous_CaMKIICaMKII-thr286
CaMKII***
  • basal_CaMKII_
    cyt

  • 2 tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM



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