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Accession Type:
Network
AMPAR_CaMKII_
weak_coupling
Shared_Object_
AMPAR_CaMKII_
weak_coupling
CaMKII
 Molecule
 Enzyme
 Reaction
CaM
PP1
PP2B
PP1_PSD
AMPAR
PKA
AC
AMPAR_memb
PP1_CaMKII_PSDPP1_CaMKII_PSD
CaMKII_PSD

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Molecule List for pathway CaMKII (Pathway Number 282)

 Name Initial Conc. (uM) Volume (fL) Buffered
1act_CaMKII_cyt20.09No
   
2basal_CaMKII_cyt20.09Yes
   
3CaMK-thr30500.09No
    This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
4CaMKII200.09No
    Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM.
5CaMKII***00.09No
    From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
6CaMKII-CaM00.09No
   
7CaMKII-thr28600.09No
    I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
8CaMKII-thr286*-CaM00.09No
    From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
9tot_autonomous_CaMKII20.09No
   
10tot_CaMKII_cyt220.09No
   
11tot_CaM_CaMKII00.09No
   

Summed Molecule List

  Target Inputs
1 act_CaMKII_cyttot_CaM_CaMKII
  • tot_autonomous_
    CaMKII

  • 2 tot_autonomous_CaMKIICaMKII-thr286
    CaMKII***
  • basal_CaMKII_
    cyt

  • 3 tot_CaMKII_cytCaMKII-CaM
  • CaMKII-thr286*-C
    aM

    CaMKII-thr286
    CaMKII***
    CaMK-thr305
    CaMKII
  • basal_CaMKII_
    cyt

  • 4 tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM



  • Pathway Details  Molecule List   Enzyme List   Reaction List  


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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