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Accession Type:
Pathway
SOCS1_knockout
SOCS1_knockoutSOCS1_knockout
 Molecule
 Enzyme
 Reaction

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Parameters for SOCS1_knockout (Pathway Number 294)

Pathway Layout

Pathway Basic Parameters

Pathway NameSOCS1_knockout
Pathway Entry Number 294
Accession Number 67
Accession Name SOCS1_knockout
Species mouse
Tissue Liver
CellCompartmentNucleus , cytoplasm
Related Pathways
Notes  This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

Statistics

45
1
47

Conversion format

This pathway is part of accession 67 and is completely specified in the file acc67.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc67.g   
MATLAB format    acc67.m   
SBML format    acc67.xml   


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