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Accession Type:
Pathway
NOHArginine
NOHArginine
 Molecule
 Reaction

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Parameters for NOHArginine (Pathway Number 311)

Pathway Layout

Pathway Basic Parameters

Pathway NameNOHArginine
Pathway Entry Number 311
Accession Number 75
Accession Name NOHArginine
Species human
Tissue Kidney cell expressing the rat brain nNOS
CellCompartmentCytosol
Related Pathways
Notes This model is taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of NOHArginine to neuronal nitric oxide synthase.
Model shows the substrate (NOH-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and NOH-Arginine to form an intermediate that contains bound imidazole and NOH-arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Rates approximated based on data in Table 2. The rates for first reaction are not exact since only Kd known and appropriate graphs do not exist for matching the kinetic profile.

Statistics

Enzyme sites
5
0
2

Conversion format

This pathway is part of accession 75 and is completely specified in the file acc75.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc75.g   
MATLAB format    acc75.m   
SBML format    acc75.xml   


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