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Accession Type:
Network
Ajay_Bhalla_
2004_PKM_Tuning
PKC
Shared_Object_
Ajay_Bhalla_
2004_PKM_tuning
PLA2
PLCbeta
 Molecule
 Enzyme
 Reaction
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
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Molecule List for pathway PLCbeta (Pathway Number 315)

 Name Initial Conc. (uM) Volume (fL) Buffered
1Inositol01.5Yes
2PC02.5E-6Yes
    Phosphatidylcholine is the main (around 55%) metabolic product of DAG, follwed by PE (around 25%). Ref is Welsh and Cabot, JCB35:231-245(1987)
3PLC0.81.5No
    Total PLC = 0.8 uM see Ryu et al JBC 262 (26) pp 12511 1987
4PLC-Ca01.5No
5PLC-Ca-Gq01.5No
    This should really be labelled PLC-G*GTP-Ca. This is the activated form of the enzyme. Mahama and Linderman assume that the IP3 precursors are not rate-limiting, but I will include those for completeness as they may be needed later.
6PLC-Gq01.5No


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