NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Network
mkp1_feedback_
effects
Shared_Object_
mkp1_feedback_
effects
 Molecule
 Enzyme
 Reaction
Sos
PKC
MAPK
PLA2
Ras
PDGFR

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Parameters for Shared_Object_mkp1_feedback_effects (Pathway Number 32)

Pathway Layout

Pathway Basic Parameters

Pathway NameShared_Object_mkp1_feedback_effects
Pathway Entry Number 32
Accession Number 4
Accession Name mkp1_feedback_effects
Species Generic mammalian
Tissue NIH 3T3 Expression
CellCompartmentSurface - nucleus
Related Pathways
Notes  This is a network involving the MAPK-PKC feedback loop with input from the PDGFR in the synapse. The distinctive feature of this model is that it includes MKP-1 induction by MAPK, and the consequent inhibitory regulation of MAPK and the feedback loop. Lots of interesting dynamics arise from this. This link provides supplementary material for the paper Bhalla US et al. Science (2002) 297(5583):1018-23. In the form of several example simulations and demos for the figures in the paper.

Statistics

12
16
2

Conversion format

This pathway is part of accession 4 and is completely specified in the file acc4.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc4.g   
GENESIS Format (Annotated version)    Anno_acc4.g   
MATLAB format    acc4.m   
SBML format    acc4.xml   


Pathway Detail   Molecule List   Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.