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Accession Type:
Network
Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Shared_Object_
Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
PKC
PLA2
PLCbeta
Ras
Gq
MAPK
EGFR
Sos
PLC_g
CaMKII
 Molecule
 Enzyme
 Reaction
CaM
PP1
PP2B
PKA
AC
MKP3
PKM

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Molecule List for pathway CaMKII (Pathway Number 339)

 Name Initial Conc. (uM) Volume (fL) Buffered
1CaMK-thr30601.5No
    This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
2CaMKII701.5No
    Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM.
3CaMKII***01.5No
    From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
4CaMKII-CaM01.5No
5CaMKII-thr28601.5No
    I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
6CaMKII-thr286*-CaM01.5No
    From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
7tot_autonomous_CaMKII01.5No
8tot_CaM_CaMKII01.5No

Summed Molecule List

  Target Inputs
1 tot_autonomous_CaMKIICaMKII-thr286
CaMKII***
2 tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM



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