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Accession Type:
Network
Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Shared_Object_
Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
PKC
PLA2
PLCbeta
Ras
Gq
MAPK
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC
 Molecule
 Enzyme
 Reaction
MKP3
PKM

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Molecule List for pathway AC (Pathway Number 344)

 Name Initial Conc. (uM) Volume (fL) Buffered
1AC10.021.5No
    Starting conc at 20 nM.
2AC1-CaM01.5No
    This version of cyclase is Calmodulin activated. Gs stims it but betagamma inhibits.
3AC1-Gs01.5No
4AC20.0151.5No
    Starting at 0.015 uM.
5AC2*01.5No
    This version is activated by Gs and by a betagamma and phosphorylation.
6AC2*-Gs01.5No
7AC2-Gs01.5No
8AMP3254932.5E-6No
9ATP50001.5Yes
    ATP is present in all cells between 2 and 10 mM. See Lehninger.
10CaM.PDE101.5No
    Activity up 6x following Ca-CaM binding.
11cAMP-PDE0.451.5No
    The levels of the PDE are not known at this time. However, enough kinetic info and info about steady-state levels of cAMP etc are around to make it possible to estimate this.
12cAMP-PDE*01.5No
    This form has about 2X activity as plain PDE. See Sette et al JBC 269:28 18271-18274 1994.
13PDE121.5No
    CaM-Dependent PDE. Amount calculated from total rate in brain vs. specific rate.


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