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Accession Type:
Network
Ajay_Bhalla_
2004_Feedback_
Tuning
Shared_Object_
Ajay_Bhalla_
2004_Feedback_
Tuning
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
 Molecule
 Reaction
PP1
PP2B
PKA
AC

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Molecule List for pathway CaM (Pathway Number 358)

 Name Initial Conc. (uM) Volume (fL) Buffered
1CaM201.5No
    There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
2neurogranin101.5No
    Also known as RC3 and p17 and BICKS. Conc in brain >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995 but others say less without any #s. Conc in dend spines is much higher than overall, so it could be anywhere from 2 uM to 50. We will estimate 10 uM as a starting point. Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no numbers) indicating CaM-Ca(n) binding ....
3neurogranin*01.5No
    The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)
4neurogranin-CaM01.5No


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