NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Network
mkp1_feedback_
effects
Shared_Object_
mkp1_feedback_
effects
Sos
PKC
MAPK
PLA2
 Molecule
 Enzyme
 Reaction
Ras
PDGFR

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Enzyme List for pathway PLA2 (Pathway Number 36)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
kenz

Enzyme Molecule:
PLA2-Ca*
205.44explicit E-S complexAPC
AA
  Based on Leslie and Channon 1990 BBA 1045:261, in relation to the other PLA2 inputs (not including MAPK). Ca alone is rather a weak input.
2 Enzyme Activity:
kenz

Enzyme Molecule:
PIP2-PLA2*
2011.044explicit E-S complexAPC
AA
  Based on Leslie and Channon 1990 BBA 1045:261.
3 Enzyme Activity:
kenz

Enzyme Molecule:
PIP2-Ca-PLA2*
20364explicit E-S complexAPC
AA
  Based on AA generation by different stimuli according to Leslie and Channon 1990 BBA 1045:261
4 Enzyme Activity:
kenz

Enzyme Molecule:
DAG-Ca-PLA2*
20604explicit E-S complexAPC
AA
  Based on Leslie and Channon 1990 BBA 1045:261.
5 Enzyme Activity:
kenz

Enzyme Molecule:
PLA2*-Ca
201204explicit E-S complexAPC
AA
  This form should be 3 to 6 times as fast as the Ca-only form, from Lin et al 1993 Cell 269-278 Nemenoff et al 1993 JBC 268:1960 Several forms contribute to the Ca-stimulated form, so this rate has to be a factor larger than their total contribution. I assign Vmax as the scale factor here because there is lots of APC substrate, so all the PLA2 complex enzymes are limited primarily by Vmax.


Pathway Details   Molecule List  Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.