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Accession Type:
Network

fig2_egfr

Shared_Object_
fig2_egfr

PKC

PLA2

PLCbeta

		Gq
		Molecule
		Reaction

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Reaction List for pathway Gq (Pathway Number 5)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.

	Name	Kf	Kb	Kd	tau	Substrate	Product
1	Activate-Gq	kf (s^-1)	0 (uM^-2 s^-1)	-	-	Rec-Glu-Gq	G*GTP BetaGamma Rec-Glu
2	Antag-bind-Rec-G q	kf (uM^-1 s^-1)	0.01 (s^-1)	Kd(bf) = 0.0002(uM)	-	Rec-Gq mGluRAntag	Blocked-rec-Gq
3	Basal-Act-G	kf (s^-1)	0 (uM^-1 s^-1)	-	-	G-GDP	G*GTP BetaGamma
4	Glu-bind-Rec-Gq	kf (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.006(uM)	-	Glu Rec-Gq	Rec-Glu-Gq
5	Inact-G	kf (s^-1)	0 (s^-1)	-	-	G*GTP	G*GDP
6	Rec-bind-Gq	kf (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 1.6667(uM)	-	G-GDP mGluR	Rec-Gq
7	Rec-Glu-bind-Gq	kf (uM^-1 s^-1)	0.0001 (s^-1)	Kd(bf) = 0.0167(uM)	-	G-GDP Rec-Glu	Rec-Glu-Gq
8	RecLigandBinding	kf (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 0.5952(uM)	-	mGluR Glu	Rec-Glu
9	Trimerize-G	kf (uM^-1 s^-1)	0 (s^-1)	-	-	G*GDP BetaGamma	G-GDP

Pathway Details Molecule List Enzyme List Reaction List

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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