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Accession Type:
Network
Synaptic_
Network
Shared_Object_
Synaptic_
Network
PKC
PLA2
 Molecule
 Enzyme
 Reaction
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC
CaRegulation

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Enzyme List for pathway PLA2 (Pathway Number 72)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
kenz

Enzyme Molecule:
PLA2-Ca*
205.44explicit E-S complexAPC
AA
  Based on Leslie and Channon 1990 BBA 1045:261, in relation to the other PLA2 inputs (not including MAPK). Ca alone is rather a weak input.
2 Enzyme Activity:
kenz

Enzyme Molecule:
PIP2-PLA2*
2011.044explicit E-S complexAPC
AA
  Based on Leslie and Channon 1990 BBA 1045:261.
3 Enzyme Activity:
kenz

Enzyme Molecule:
PIP2-Ca-PLA2*
20364explicit E-S complexAPC
AA
  Based on AA generation by different stimuli according to Leslie and Channon 1990 BBA 1045:261
4 Enzyme Activity:
kenz

Enzyme Molecule:
DAG-Ca-PLA2*
20604explicit E-S complexAPC
AA
  Based on Leslie and Channon 1990 BBA 1045:261.
5 Enzyme Activity:
kenz

Enzyme Molecule:
PLA2*-Ca
201204explicit E-S complexAPC
AA
  This form should be 3 to 6 times as fast as the Ca-only form, from Lin et al 1993 Cell 269-278 Nemenoff et al 1993 JBC 268:1960 Several forms contribute to the Ca-stimulated form, so this rate has to be a factor larger than their total contribution. I assign Vmax as the scale factor here because there is lots of APC substrate, so all the PLA2 complex enzymes are limited primarily by Vmax.


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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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