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Accession Type:
Network
Synaptic_
Network
Shared_Object_
Synaptic_
Network
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
 Molecule
 Reaction
AC
CaRegulation

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Molecule List for pathway PKA (Pathway Number 84)

 Name Initial Conc. (uM) Volume (fL) Buffered
1inhibited-PKA01000No
    This is the inhibitor bound to PKA.
2PKA-inhibitor0.251000No
    About 25% of PKA C subunit is dissociated in resting cells without having any noticable activity. Doskeland and Ogreid Int J biochem 13 pp1-19 suggest that this is because there is a corresponding amount of inhibitor protein.
3R2-cAMP401000No
    The regulatory subunit with 4 cAMPs but the catalytic subunit has been released.
4R2C-cAMP401000No
   
5R2C20.51000No
    This is the R2C2 complex, consisting of 2 catalytic (C) subunits, and the R-dimer. See Taylor et al Ann Rev Biochem 1990 59:971-1005 for a review. The Doskeland and Ogreid review is better for numbers. Amount of PKA is about .5 uM.
6R2C2-cAMP01000No
    One cAMP bound to site B1 on the regulatory subunits.
7R2C2-cAMP201000No
    One cAMP bound to each of the B sites on the regulatory subunits.
8R2C2-cAMP301000No
    3 cAMPs now bound.
9R2C2-cAMP401000No
    All the regulatory subunits now have cAMP bound. This state is ready to dissociate and to release the catalytic subunit.


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