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Accession Type:
Network
Synaptic_
Network
Shared_Object_
Synaptic_
Network
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC
CaRegulation
 Molecule
 Enzyme
 Reaction

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Enzyme List for pathway CaRegulation (Pathway Number 86)

 Molecule Name/
Site Name
Km (uM) kcat (1/s)Ratio
(k2/k3)
Enzyme TypeSubstrate Product
1 Enzyme Activity:
Ca-pump-out

Enzyme Molecule:
CaEPump
0.2724explicit E-S complexCa_intracell
Ca-ext
  From McBurney and Neering TINS 10(4) 164-169 1987. We are using the high-affinity pump here, Their numbers exceed M&L so I am reducing the rates by 10X. Need to check. k1 = 3e-3, k2 = 288, k3 = 72, n = 1000. This comes to a Km of 0.2 for Ca, and a Vmax of 72.


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