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Accession Type:
Network
Ajay_Bhalla_
2007_ReacDiff2
Shared_Object_
Ajay_Bhalla_
2007_ReacDiff
PKC
MAPK
Ras
CaM
PKM
chain
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[1]
PKC
MAPK
Ras
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[3]
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[2]
PKC
MAPK
Ras
CaM
PKM
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[4]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[5]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[6]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[7]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[8]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[9]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[10]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[11]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[12]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[13]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[14]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[15]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[16]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[17]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[18]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[19]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[20]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[21]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[22]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[23]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[24]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[25]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[26]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[27]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[28]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[29]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[30]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[31]
PKC
 Molecule
 Reaction
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[32]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[33]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[34]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[35]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[36]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[37]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[38]
PKC
MAPK
Ras
CaM
PKM

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Reaction List for pathway PKC (Pathway Number 871)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 PKC-act-by-Cakf
(uM^-1 s^-1)
0.5
(s^-1)
Kd(bf) = 0.8333(uM)-PKC-cytosolic
Ca
PKC-Ca
  Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
2 PKC-act-by-DAGkf
(uM^-1 s^-1)
8.6348
(s^-1)
Kd(bf) = 1079.4148(uM)-PKC-Ca
DAG
PKC-Ca-DAG
  Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
3 PKC-Ca-to-membkf
(s^-1)
3.5026
(s^-1)
Keq = 2.7569(uM)0.21secPKC-Ca
PKC-Ca-memb*
4 PKC-DAG-to-membkf
(s^-1)
0.1
(s^-1)
Keq = 0.1(uM)0.909secPKC-Ca-DAG
PKC-DAG-memb*
  Raise kb from .087 to 0.1 to match data from Shinomura et al. Lower kf from 1.155 to 1.0 to match data from Shinomura et al.
5 PKC-n-DAGkf
(uM^-1 s^-1)
0.1
(s^-1)
Kd(bf) = 166.6664(uM)-PKC-cytosolic
DAG
PKC-DAG
  kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9


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