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Pathway List for pkc

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Entries are color tagged depending on Network  or Pathway 
#134#134#134#134#134#134#134#134#134#134#134#134#134#134#134#134#134#134#134#134
  Pathway Name
Pathway No.
Accession Name
Accession No.
Accession
Type
Pathway statisticspkc statisticsSource
Entry Date
21 PKC
Pathway No. 963
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956969974981987993
99910041010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
22 PKC
Pathway No. 969
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963974981987993
99910041010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
23 PKC
Pathway No. 974
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969981987993
99910041010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
24 PKC
Pathway No. 981
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974987993
99910041010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
25 PKC
Pathway No. 987
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981993
99910041010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
26 PKC
Pathway No. 993
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
99910041010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
27 PKC
Pathway No. 999
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
99310041010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
28 PKC
Pathway No. 1004
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991010101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
29 PKC
Pathway No. 1010
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101610221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
30 PKC
Pathway No. 1016
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010221028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
31 PKC
Pathway No. 1022
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161028103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
32 PKC
Pathway No. 1028
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161022103410401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
33 PKC
Pathway No. 1034
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161022102810401046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
34 PKC
Pathway No. 1040
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161022102810341046105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
35 PKC
Pathway No. 1046
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161022102810341040105210581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
36 PKC
Pathway No. 1052
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161022102810341040104610581064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
37 PKC
Pathway No. 1058
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161022102810341040104610521064
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
38 PKC
Pathway No. 1064
 Ajay_Bhalla_
2007_ReacDiff3

Accession No. 84
NetworkMolecule = 11
Enzyme   = 0
Reaction  = 10
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678685691698
703709715721727733739745751757763769775781787793799805811817823829835841
847853859865871877883889895901907913919927932938944950956963969974981987
9939991004101010161022102810341040104610521058
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.
   
This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway.
FormatFile
39 PKC
Pathway No. 678
 Ajay_Bhalla_
2007_ReacDiff2

Accession No. 83
NetworkMolecule = 7
Enzyme   = 0
Reaction  = 5
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672685691698703
709715721727733739745751757763769775781787793799805811817823829835841847
853859865871877883889895901907913919927932938944950956963969974981987993
99910041010101610221028103410401046105210581064
    This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.
   
This pathway is part of accession 83 and is completely specified in the file acc83.g.
There is no separate for just this pathway.
FormatFile
40 PKC
Pathway No. 685
 Ajay_Bhalla_
2007_ReacDiff2

Accession No. 83
NetworkMolecule = 7
Enzyme   = 0
Reaction  = 5
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
22034556071108123138147161181200207313330348364370376383389395401408
414420426431437443449455461467473479485491497503509515521527534540546552
558564570576582588594600606612618624630636642648654660666672678691698703
709715721727733739745751757763769775781787793799805811817823829835841847
853859865871877883889895901907913919927932938944950956963969974981987993
99910041010101610221028103410401046105210581064
    This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.
   
This pathway is part of accession 83 and is completely specified in the file acc83.g.
There is no separate for just this pathway.
FormatFile

 
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