NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By


 
Result: 1 - 20 of 129 rows are displayed Previous of 7  Next

Pathway List for ras

Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering.
indicates that ordering is done according to ascending or descending order.
Entries are color tagged depending on Network  or Pathway 
#129#129#129#129#129#129#129#129#129#129#129#129#129#129#129#129#129#129#129#129
  Pathway Name
Pathway No.
Accession Name
Accession No.
Accession
Type
Pathway statisticsras statisticsSource
Entry Date
1 Ras
Pathway No. 7
 fig2_egfr

Accession No. 1
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00
   Related Pathway: 
2537586376184212231318333353367372378385391397404410416422427433439
445451457463469475481487493499505511517523529536542548554560566572578584
590596602608614620626632638644650656662668674680687693700705711717723729
735741747753759765771777783789795801807813819825831837843849855861867873
879885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.
   
This pathway is part of accession 1 and is completely specified in the file acc1.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc1.g   
GENESIS Format (Annotated version)    Anno_acc1.g   
2 Ras
Pathway No. 25
 fig4_synapse

Accession No. 3
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00
   Related Pathway: 
737586376184212231318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.
   
This pathway is part of accession 3 and is completely specified in the file acc3.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc3.g   
GENESIS Format (Annotated version)    Anno_acc3.g   
3 Ras
Pathway No. 37
 mkp1_feedback_
effects

Accession No. 4
NetworkMolecule = 6
Enzyme   = 2
Reaction  = 3
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication )/
2001-11-07 00:00:00
   Related Pathway: 
725586376184212231318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    The main refs for Ras are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 25542-25546
   
This pathway is part of accession 4 and is completely specified in the file acc4.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc4.g   
GENESIS Format (Annotated version)    Anno_acc4.g   
MATLAB format    acc4.m   
SBML format    acc4.xml   
4 Ras
Pathway No. 58
 3d_fold_model

Accession No. 8
NetworkMolecule = 6
Enzyme   = 2
Reaction  = 3
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-08 00:00:00
   Related Pathway: 
725376376184212231318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 8 and is completely specified in the file acc8.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc8.g   
GENESIS Format (Annotated version)    Anno_acc8.g   
MATLAB format    acc8.m   
SBML format    acc8.xml   
5 Ras
Pathway No. 63
 MAPK_MKP1_
oscillation

Accession No. 9
NetworkMolecule = 6
Enzyme   = 2
Reaction  = 3
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. ( peer-reviewed publication )/
2001-11-08 00:00:00
   Related Pathway: 
725375876184212231318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 9 and is completely specified in the file acc9.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc9.g   
GENESIS Format (Annotated version)    Anno_acc9.g   
GENESIS Format (Annotated version)    Anno_acc9.g   
MATLAB format    acc9.m   
SBML format    acc9.xml   
6 Ras
Pathway No. 76
 Synaptic_
Network

Accession No. 16
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-12-12 00:00:00
   Related Pathway: 
725375863184212231318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    The main refs for Ras are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 25542-25546
   
This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc16.g   
GENESIS Format (Annotated version)    Anno_acc16.g   
7 Ras
Pathway No. 184
 MAPK-bistability
-fig1c

Accession No. 35
NetworkMolecule = 6
Enzyme   = 2
Reaction  = 3
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US et al. Science (2002) 297(5583):1018-23 ( peer-reviewed publication )./
2002-11-07 00:00:00
   Related Pathway: 
72537586376212231318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    The main refs for Ras are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 25542-25546
   
This pathway is part of accession 35 and is completely specified in the file acc35.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc35.g   
GENESIS Format (Annotated version)    Anno_acc35.g   
MATLAB format    acc35.m   
SBML format    acc35.xml   
8 Ras
Pathway No. 212
 MAPK_network_
2003

Accession No. 50
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/
2003-04-28 00:00:00
   Related Pathway: 
72537586376184231318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 50 and is completely specified in the file acc50.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc50.g   
GENESIS Format (Annotated version)    Anno_acc50.g   
MATLAB format    acc50.m   
SBML format    acc50.xml   
9 Ras
Pathway No. 231
 EGFR_MAPK

Accession No. 58
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Bhalla US. Biophys J. (2004) 87(2):745-53. ( peer-reviewed publication )/
2004-01-14 00:00:00
   Related Pathway: 
72537586376184212318333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 58 and is completely specified in the file acc58.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc58.g   
GENESIS Format (Annotated version)    Anno_acc58.g   
MATLAB format    acc58.m   
SBML format    acc58.xml   
10 Ras
Pathway No. 318
 Ajay_Bhalla_
2004_PKM_Tuning

Accession No. 76
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12 00:00:00
   Related Pathway: 
72537586376184212231333353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 76 and is completely specified in the file acc76.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc76.g   
MATLAB format    acc76.m   
SBML format    acc76.xml   
11 Ras
Pathway No. 333
 Ajay_Bhalla_
2004_PKM_MKP3_
Tuning

Accession No. 77
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80 ( Peer-reviewed publication )/
2006-12-12 00:00:00
   Related Pathway: 
72537586376184212231318353367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 77 and is completely specified in the file acc77.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc77.g   
MATLAB format    acc77.m   
SBML format    acc77.xml   
12 Ras
Pathway No. 353
 Ajay_Bhalla_
2004_Feedback_
Tuning

Accession No. 78
NetworkMolecule = 9
Enzyme   = 4
Reaction  = 6
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12 00:00:00
   Related Pathway: 
72537586376184212231318333367372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 78 and is completely specified in the file acc78.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc78.g   
MATLAB format    acc78.m   
SBML format    acc78.xml   
13 Ras
Pathway No. 367
 Ajay_Bhalla_
2007_Bistable

Accession No. 79
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353372378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 79 and is completely specified in the file acc79.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc79.g   
MATLAB format    acc79.m   
SBML format    acc79.xml   
14 Ras
Pathway No. 372
 Ajay_Bhalla_
2007_PKM

Accession No. 80
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353367378385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 80 and is completely specified in the file acc80.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc80.g   
MATLAB format    acc80.m   
SBML format    acc80.xml   
15 Ras
Pathway No. 378
 Ajay_bhalla_
2007_ReacDiff1_
1e-12

Accession No. 81
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353367372385391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 81 and is completely specified in the file acc81.g.
There is no separate for just this pathway.
FormatFile
16 Ras
Pathway No. 385
 Ajay_bhalla_
2007_ReacDiff1_
1e-12

Accession No. 81
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353367372378391397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 81 and is completely specified in the file acc81.g.
There is no separate for just this pathway.
FormatFile
17 Ras
Pathway No. 391
 Ajay_bhalla_
2007_ReacDiff1_
1e-12

Accession No. 81
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353367372378385397404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 81 and is completely specified in the file acc81.g.
There is no separate for just this pathway.
FormatFile
18 Ras
Pathway No. 397
 Ajay_bhalla_
2007_ReacDiff1_
1e-12

Accession No. 81
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353367372378385391404410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 81 and is completely specified in the file acc81.g.
There is no separate for just this pathway.
FormatFile
19 Ras
Pathway No. 404
 Ajay_bhalla_
2007_ReacDiff1_
1e-12

Accession No. 81
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353367372378385391397410416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 81 and is completely specified in the file acc81.g.
There is no separate for just this pathway.
FormatFile
20 Ras
Pathway No. 410
 Ajay_bhalla_
2007_ReacDiff1_
1e-12

Accession No. 81
NetworkMolecule = 7
Enzyme   = 4
Reaction  = 4
Molecule = 0
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00
   Related Pathway: 
72537586376184212231318333353367372378385391397404416422427433439445
451457463469475481487493499505511517523529536542548554560566572578584590
596602608614620626632638644650656662668674680687693700705711717723729735
741747753759765771777783789795801807813819825831837843849855861867873879
885891897903909915923929935941947953959966972978984990996100110071013
101910251031103710431049105510611067
    Ras has now gotten to be a big enough component of the model to deserve its own group. The main refs are Boguski and McCormick Nature 366 643-654 '93 Major review Eccleston et al JBC 268:36 pp 27012-19 Orita et al JBC 268:34 2554246
   
This pathway is part of accession 81 and is completely specified in the file acc81.g.
There is no separate for just this pathway.
FormatFile

 
Result: 1 - 20 of 129 rows are displayed Previous of 7  Next



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.