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Molecule Parameter List for CaMCa4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMCa4* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	3	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII	33	Network	Shared_Object_CaMKII, CaM, CaMKII, CaN
This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.

CaMCa4 acting as a Molecule in CaMKII Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMCa4	CaMKII Accession No. : 33	CaM Pathway No. : 173	0	0.1309	No

CaMCa4 acting as a Substrate in a reaction in CaMKII Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMKII-bind-CaMC a4	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	100.004 (uM^-1 s^-1)	4.5 (s^-1)	Kd(bf) = 0.045(uM)	-	Substrate CaMCa4 CaMKII Product CaMKII-CaMCa4
2	Autonomous-bind- CaMCa4	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	33.2998 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate Autonomous CaMCa4 Product Trapped-T286
3	CaN-bind-CaMCa4	CaMKII Accession No. : 33	CaN Pathway No. : 175	100.004 (uM^-1 s^-1)	0.6 (s^-1)	Kd(bf) = 0.006(uM)	-	Substrate CaMCa4 CaN Product CaN-CaMCa4

CaMCa4 acting as a Product in a reaction in CaMKII Network

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMCa3-bind-Ca	CaMKII Accession No. : 33	CaM Pathway No. : 173	100.004 (uM^-1 s^-1)	500 (s^-1)	Kd(bf) = 4.9998(uM)	-	Substrate Ca CaMCa3 Product CaMCa4
2	Autonomous_ lose_CaMCa4	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	0.02 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate Trapped-T286 Product Autonomous CaMCa4
	Holmes says that this rate is variable, and depends on Ca conc. It is 0.1 when [Ca] = 10 nM, and 0.00355/sec when [Ca] is 1.0 For our purposes, we assume a good steady approx to this rate is 0.02.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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