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Accession information for EGFR_Signaling_pathway (Accession Number 52)
Accession Basic Parameters
| Name ||EGFR_Signaling_pathway |
| Accession Type ||Pathway|
| Transcriber ||Pradeep Kumar S, NCBS|
| Developer ||Kholodenko et al|
| Entry Date (YYYY-MM-DD) || 2003-05-17|
| Species ||Harlan Sprague Dawley rat; mammalian|
| Tissue ||Hepatocytes|
| Cell Compartment ||Cell membrane + cytosol|
| Source ||Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. ( peer-reviewed publication )|
| Methodology ||Qualitative|
| Model Implementation ||Mathematically equivalent|
| Model Validation ||Approximates original data|
| Notes || This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. |
Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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