NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Pathway
EGFR_Signaling_
pathway
EGFR

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Accession information for EGFR_Signaling_pathway (Accession Number 52)

Reaction Scheme

Accession Basic Parameters

Name EGFR_Signaling_pathway
Accession Type Pathway
Transcriber Pradeep Kumar S, NCBS
Developer Kholodenko et al
Entry Date (YYYY-MM-DD) 2003-05-17
Species Harlan Sprague Dawley rat; mammalian
Tissue Hepatocytes
Cell Compartment Cell membrane + cytosol
Source Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. ( peer-reviewed publication )
Methodology Qualitative
Model Implementation Mathematically equivalent
Model Validation Approximates original data
Notes This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999.
Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc52.g   
GENESIS Format (Annotated version)    Anno_acc52.g   
SBML format    acc52.xml   



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.