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Accession information for Quorum_repressilator (Accession Number 69)
Accession Basic Parameters
| Name ||Quorum_repressilator |
| Accession Type ||Network|
| Transcriber || Sharat J. Vayttaden and Pragati Jain, NCBS|
| Developer ||Jordia Garcia-Ojalvo, Elowitz and Strogatz|
| Entry Date (YYYY-MM-DD) || 2006-02-14|
| Species ||E. Coli|
| Tissue ||E.coli Expression, Transposon Tn10, Lambda phage Expression|
| Cell Compartment ||Cytosol, Extracellular|
| Source || Garcia-Ojalvo J, Elowitz MB, Strogatz SH. Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10955-60.. ( Peer-reviewed publication )|
| Methodology ||Qualitative|
| Model Implementation ||Exact GENESIS implementation|
| Model Validation ||Approximates original data |
| Notes || This model represents a single cell with the repressilator circuit, which is part of a population of similar cells. The repressilator circuit is a network of three proteins, i.e. LacI, TetR, Lambda-cI. |
The single repressilator model is at accession number 68 in the DOQCS database.
In the current model, the LacI is coupled with LuxI which forms an Autoinducer(AI) protein, which couples to LuxR which activates LacI. The AI protein difffuses across the cell membrane so that the population of cells can interact. The lifetime ratio is the ratio between the mRNA and protein lifetimes. This ratio in different cells is chosen from a random gaussian distribution of mean 1 and standard deviation 0.05. The lifetime ratio of this example cell is 0.9837
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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