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Pathway
L-Arginine
L-Arginine

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Accession information for L-Arginine (Accession Number 72)

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Accession Basic Parameters

Name L-Arginine
Accession Type Pathway
Transcriber Sharat J. Vayttaden and Prasoon Agarwal, NCBS
Developer Abu-Soud HM, Wang J, Rousseau DL, and Stuehr DJ
Entry Date (YYYY-MM-DD) 2006-08-07
Species Human
Tissue Kidney cell expressing the rat brain nNOS
Cell Compartment Cytosol
Source Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication )
Methodology Quantitative match to experiments
Model Implementation Exact GENESIS implementation
Model Validation Approximates original data
Notes This model was taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of L-Arginine to neuronal nitric oxide synthase.
Model shows the substrate (L-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and L-Arginine to form an intermediate that contains bound imidazole and L-Arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Replicates Figure 4 (right panel).

Conversion formats

FormatFile
Native Format (GENESIS format)    acc72.g   
MATLAB format    acc72.m   
SBML format    acc72.xml   



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