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Accession Type:
Network
Mammalian_cell_
cycle
Growth
CELLDIV
Rb_grp
IE_GRP
CycB_Grp
Cdc20_Grp
Cdh1_grp
E2F
CycA_Grp
CycE_grp
Early_Response_
Genes
Delayed_
Response_Genes
CycD_Grp

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Accession information for Mammalian_cell_cycle (Accession Number 85)

Reaction Scheme

Accession Basic Parameters

Name Mammalian_cell_cycle
Accession Type Network
Transcriber Upinder S. Bhalla, NCBS
Developer Bela Novak and John J. Tyson.
Entry Date (YYYY-MM-DD) 2006-12-21
Species General Mammalian
Tissue -
Cell Compartment Nucleus
Source Novak B,Tyson JJ. J Theor Biol. 2004 Oct 21;230(4):563-79. ( Peer-reviewed publication )
Methodology Quantitative match to experiments
Model Implementation Approximate implementation
Model Validation Approximates original data
Notes This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc85.g   



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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