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Enzyme List for pathway PLC_g (Pathway Number 79) in Accession Synaptic_Network (Accession Number 16)

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  Enzyme Molecule /

 Enzyme Activity		Pathway Name / 
Pathway No.		Km
(uM)		kcat
(s^-1)		Ratio
(k2/k3)		Enzyme TypeReagents
1 Ca.PLC_g /
PIP2_hydrolysis		PLC_g

Pathway No. 79		97.2222144Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S		Substrate: 
PIP2
Product : 
DAG
IP3
  Wahl et al JBC 267(15) 10447-10456 1992. Homma et al JBC 263:14 1988 pp 6592. These parms are the Ca-stimulated form. This is close to Wahl's figure 7, which I am using as reference. Also see Nakanishi et al Biochem J 256 453-459 1998, Nishibe et al Science 250 :1253-1256 This model uses a rather low PIP2 of 10 uM.
2 Ca.PLC_g* /
PIP2_hydrolysis		PLC_g

Pathway No. 79		19.7917574Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S		Substrate: 
PIP2
Product : 
DAG
IP3
  Mainly Homma et al JBC 263:14 1988 pp 6592. These parms are the Ca-stimulated form. Wahl et al JBC 267:15 10447-10456 1992 say that the tyrosine phosphorylated form has 7X higher affinity for substrate than control. The PIP2 levels in this model are rather low, at 10 uM.
 
Result: 1 - 2 of 2 rows are displayed


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