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Result: 1 - 4 of 4 rows are displayed

Enzyme List for pathway CaMKII (Pathway Number 80) in Accession Synaptic_Network (Accession Number 16)

Entries are grouped according to Pathway Number and they are alternately color coded using  and   color.
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  Enzyme Molecule /

 Enzyme Activity
Pathway Name / 
Pathway No.
Km
(uM)
kcat
(s^-1)
Ratio
(k2/k3)
Enzyme TypeReagents
1 tot_CaM_CaMKII /
CaM_act_305
CaMKII

Pathway No. 80
2.70563e-0664explicit E-S complexSubstrate: 
CaMKII-thr286
Product : 
CaMKII***
  Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
2 tot_CaM_CaMKII /
CaM_act_286
CaMKII

Pathway No. 80
2.70563e-060.54explicit E-S complexSubstrate: 
CaMKII-CaM
Product : 
CaMKII-thr286*-C
aM

  See Hanson and Schulman 1992 JBC 267(24):17216-17224
3 
  • tot_autonomous_
    CaMKII
    /
    auton_305
  • CaMKII

    Pathway No. 80
    4.16667e-0664explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII***
      See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
    4 
  • tot_autonomous_
    CaMKII
    /
    auton_286
  • CaMKII

    Pathway No. 80
    4.16667e-060.54explicit E-S complexSubstrate: 
    CaMKII-CaM
    Product : 
    CaMKII-thr286*-C
    aM

      The autonomous rate has a slightly higher Km than the CaM-bound rate, but Vmax is the same. Hanson and Schulman 1992 Ann Rev Biochem 61:559-601 and Hanson and Schulman 1992 JBC 267(24):17216-17224

     
    Result: 1 - 4 of 4 rows are displayed



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