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Molecule List for pathway PLA2 (Pathway Number 62) in Accession MAPK_MKP1_oscillation (Accession Number 9)
| Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.|
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The entries are grouped according to Pathway Number and are alternately color coded using and color.
|Buffered||Sum Total Of|
|1|| APC||Network||30||1000||Yes||- |
| || arachodonylphosphatidylcholine is the favoured substrate from Wijkander and Sundler, JBC 202 pp 873-880, 1991. Their assay used 30 uM substrate, which is what the kinetics in this model are based on. For the later model we should locate a more realistic value for APC.|
|2|| DAG-Ca-PLA2*||Network||0||1000||No||- |
|3|| PIP2-Ca-PLA2*||Network||0||1000||No||- |
|4|| PIP2-PLA2*||Network||0||1000||No||- |
|5|| PLA2*||Network||0||1000||No||- |
|6|| PLA2*-Ca||Network||0||1000||No||- |
| || Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.|
|7|| PLA2-Ca*||Network||0||1000||No||- |
|8|| PLA2-cytosolic||Network||0.4||1000||No||- |
| || Calculated cytosolic was 20 nm from Wijkander and Sundler However, Leslie and Channon use about 400 nM. Need to confirm, but this is the value I use here. Another recalc of W&S gives 1uM|
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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