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Molecule List for pathway PP1 (Pathway Number 82) in Accession Synaptic_Network (Accession Number 16)
| Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.|
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The entries are grouped according to Pathway Number and are alternately color coded using and color.
|Buffered||Sum Total Of|
|1|| I1||Network||1.8||1000||No||- |
| || I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183). We treat it as non-competitive, so it just turns the enzyme off without interacting with the binding site. Cohen et al 1989 Ann rev Biochem 58:453-508 refer to results where concentration of the inhibitor is 1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM, we need >= 1.8 uM. |
|2|| I1*||Network||0.001||1000||No||- |
| || Phosphorylated form of the inhibitor. This has a high affinity for the PP1 catalytic subunit. Upon binding the PP1 is inactivated. Cohen 1989 Ann Rev Biochem 58:453-508|
|3|| PP1-I1||Network||0||1000||No||- |
| || This form is bound to the non-phosphorylated inibitory subunit and is prone to dissociate. Cohen 1989 Ann Rev biochem 58:453-508|
|4|| PP1-I1*||Network||0||1000||No||- |
| || This form has the inibitory fragment phosphorylated. The binding of PP1 is tight when the inhibitory fragment is phosphorylated Cohen 1989 Ann Rev Biochem 58:453-508|
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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