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Accession Type:
Network
NonOsc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
 Molecule
 Enzyme
 Reaction
IP3-3K
CaRegulation
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos

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Parameters for PKC (Pathway Number 108)

Pathway Layout

Pathway Basic Parameters

Pathway NamePKC
Pathway Entry Number 108
Accession Number 23
Accession Name NonOsc_Ca_IP3metabolism
Species Generic mammalian
Tissue Brain - Neuronal
CellCompartmentCytosol
Related Pathways 2, 20, 34, 55, 60, 71, 123, 138, 147, 161, 181, 200, 207, 313, 330, 348, 364, 370, 376, 383, 389, 395, 401, 408, 414, 420, 426, 431, 437, 443, 449, 455, 461, 467, 473, 479, 485, 491, 497, 503, 509, 515, 521, 527, 534, 540, 546, 552, 558, 564, 570, 576, 582, 588, 594, 600, 606, 612, 618, 624, 630, 636, 642, 648, 654, 660, 666, 672, 678, 685, 691, 698, 703, 709, 715, 721, 727, 733, 739, 745, 751, 757, 763, 769, 775, 781, 787, 793, 799, 805, 811, 817, 823, 829, 835, 841, 847, 853, 859, 865, 871, 877, 883, 889, 895, 901, 907, 913, 919, 927, 932, 938, 944, 950, 956, 963, 969, 974, 981, 987, 993, 999, 1004, 1010, 1016, 1022, 1028, 1034, 1040, 1046, 1052, 1058, 1064, 1104
NotesProtein Kinase C. This module represents a weighted average of the alpha, beta and gamma isoforms. It takes inputs from Ca, DAG (Diacyl Glycerol) and AA (arachidonic acid). Regulation parameters are largely from Schaechter JD, Benowitz LI J Neurosci. 1993 Oct;13(10):4361-71 who use synaptosomes from mammalian brain and in one paper look at all three inputs. Shinomura T et al Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5149-53 is also a useful source of data and helps to tighten the DAG inputs. General reviews include Azzi A et. al Eur J Biochem. 1992 Sep 15;208(3):547-57 and Nishizuka Y.Nature. 1988 Aug 25;334(6184):661-5. Concentration info from Kikkawa U.et al J Biol Chem. 1982 Nov 25;257(22):13341-8. The process of parameterization is described in detail in several places. See Supplementary notes to Weng G et al, Science. 1999 Apr 2;284(5411):92-6 available at the site http://www.ncbs.res.in/~bhalla/ltploop/ltploop/pkc_example.html. The parameterization is also described in a book chapter: Bhalla, 2000: Simulations of Biochemical Signaling in Computational Neuroscience: Realistic Modeling for Experimentalists. Ed. E. De Schutter. CRC Press.

Statistics

13
1
10

Conversion format

This pathway is part of accession 23 and is completely specified in the file acc23.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc23.g   
GENESIS Format (Annotated version)    Anno_acc23.g   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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