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Accession Type:
Network
NonOsc_Ca_
IP3metabolism
MIPP
CaMKII
 Molecule
 Enzyme
 Reaction
CaM
PKC
IP3-3K
CaRegulation
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos

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Parameters for CaMKII (Pathway Number 145)

Pathway Layout

Pathway Basic Parameters

Pathway NameCaMKII
Pathway Entry Number 145
Accession Number 31
Accession Name NonOsc_Ca_IP3metabolism
Species Generic mammalian
Tissue Brain - Neuronal
CellCompartmentCytosol
Related Pathways 13, 26, 80, 106, 121, 159, 174, 202, 216, 235, 245, 258, 264, 272, 282, 322, 339, 357
Notes Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzymes look a bit complicated. Actually it is just 3 reactions for different sites, by 4 states of CaMKII, defined by the phosphorylation state. This model approximates the fact that the enzyme is actually present as a decamer/dodecamer. It does so by treating the autophosphorylation reactions as being independent of the concentration of CaMKII. Also the rates for the autophosphorylation steps have been scaled to fit this approximation.

Statistics

10
13
3

Conversion format

This pathway is part of accession 31 and is completely specified in the file acc31.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc31.g   
GENESIS Format (Annotated version)    Anno_acc31.g   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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